Identifying and understanding psychosocial predictors related to an agent’s propensity to disengage from their own moral self-sanctions is important in decreasing self-destructive behaviors. Here we present research related to certain religious connections to moral disengagement. An analysis of the data allows for an evaluation of possible reasons for correlations and predictability between three different aspects of religious practice and a propensity for the disengagement of moral self-sanctions. Discussion on the possible benefits and risks related to intrinsic religiosity, organized religious practice, and non-organized religious practice is offered to explore theoretical and pragmatic implications. Conclusions include the need for further research to assist in better understanding how religious practice might influence an agent to act in accord or disaccord with their own ethical beliefs whilst either improving moral resilience or otherwise assuaging anguish and cognitive dissonance that often results from contradicting one’s principled moral beliefs.